Epigenetic Mechanisms in Autism Spectrum Disorders
نویسندگان
چکیده
منابع مشابه
Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms
Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single gene disorders associated with an increased risk for autism. Furthermore, sever...
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Recent studies have firmly established that the etiology of autism includes both genetic and environmental components. However, we are only just beginning to elucidate the environmental factors that might be involved in the development of autism, as well as the molecular mechanisms through which they function. Mounting epidemiological and biological evidence suggest that prenatal factors that i...
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The pathogenesis of autism spectrum disorder (ASD) likely involves genetic and environmental factors, impacting the complex neurodevelopmental and behavioral abnormalities of the disorder. Scientific researches emerging within the past two decades suggest that immune dysfunction and inflammation have pathogenic influences through different mechanisms, all leading to both a chronic state of low ...
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In recent years, more attention has been given to some childhood neurological disorders like include autism. Autism is a disorder that causes difficulties to language skills, the performance of social skills, and represents repetitive, stereotypic movements and non-functional behaviour patterns. During the 1970s, the prevalence of autism in the United States ranged from 1 to 3 in 10,000. In th...
متن کاملEpigenetics of autism spectrum disorders.
The autism spectrum disorders (ASD) comprise a complex group of behaviorally related disorders that are primarily genetic in origin. Involvement of epigenetic regulatory mechanisms in the pathogenesis of ASD has been suggested by the occurrence of ASD in patients with disorders arising from epigenetic mutations (fragile X syndrome) or that involve key epigenetic regulatory factors (Rett syndrom...
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